InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENDOG

Summary

InnateDB Protein

IDBP-88696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENDOG

Protein Name

endonuclease G

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361725

InnateDB Gene

IDBG-88694 (ENDOG)

Protein Structure

UniProt Annotation

Function

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006309	apoptotic DNA fragmentation
GO:0006310	DNA recombination
GO:0034612	response to tumor necrosis factor
GO:0043065	positive regulation of apoptotic process
GO:0046677	response to antibiotic