InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE4B

Summary

InnateDB Protein

IDBP-88843.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE4B

Protein Name

ubiquitination factor E4B

Synonyms

E4; HDNB1; UBOX3; UFD2; UFD2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000253251

InnateDB Gene

IDBG-88839 (UBE4B)

Protein Structure

UniProt Annotation

Function

Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen. {ECO:0000269PubMed:11802788}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	77 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0019899	enzyme binding
GO:0034450	ubiquitin-ubiquitin ligase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0009411	response to UV
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process