InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTO1

Summary

InnateDB Protein

IDBP-88850.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTO1

Protein Name

glutathione S-transferase omega 1

Synonyms

GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000358727

InnateDB Gene

IDBG-88848 (GSTO1)

Protein Structure

UniProt Annotation

Function

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269PubMed:10783391, ECO:0000269PubMed:11511179, ECO:0000269PubMed:17226937, ECO:0000269PubMed:18028863, ECO:0000269PubMed:21106529}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:11511179}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO:0000269PubMed:10783391}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0045174	glutathione dehydrogenase (ascorbate) activity
GO:0050610	methylarsonate reductase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014810	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0019852	L-ascorbic acid metabolic process
GO:0042178	xenobiotic catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071243	cellular response to arsenic-containing substance
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR005442 Glutathione S-transferase, omega-class
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM