Version 5.4
Homo sapiens Protein: UNKL
Summary
InnateDB Protein IDBP-8888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNKL
Protein Name unkempt homolog (Drosophila)-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000248104
InnateDB Gene IDBG-8886 (UNKL)
Protein Structure
UniProt Annotation
Function May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269PubMed:20148946}.
Subcellular Localization Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
PFAM PF13639
PF14634
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H9P5
PhosphoSite PhosphoSite-Q9H9P5
TrEMBL
UniProt Splice Variant
Entrez Gene 64718
UniGene Hs.697026
RefSeq NP_001263343
HUGO HGNC:14184
OMIM
CCDS CCDS61787
HPRD 15612
IMGT
EMBL AE006467 AK022685 AK027013 AL031709 AL031721 AL032819 AM944365 BC000150 BC011924 CH471112
GenPept AAH00150 AAH11924 AAK61278 AAK61279 BAB14178 BAB15626 CAM26346 CAM26360 CAM26361 CAM26438 CAM26439 CAM26441 CAQ08606 CAQ10206 CAQ16184 EAW85659 EAW85660 EAW85662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca