InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNGA2

Summary

InnateDB Protein

IDBP-88975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNGA2

Protein Name

cyclic nucleotide gated channel alpha 2

Synonyms

CNCA; CNCA1; CNG2; OCNC1; OCNCa; OCNCALPHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000328478

InnateDB Gene

IDBG-88973 (CNGA2)

Protein Structure

UniProt Annotation

Function

Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005516	calmodulin binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding

Biological Process

GO:0006811	ion transport
GO:0007603	phototransduction, visible light
GO:0007608	sensory perception of smell
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport