InnateDB Protein
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IDBP-88993.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CRAT
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Protein Name
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carnitine O-acetyltransferase
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Synonyms
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CAT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000315013
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InnateDB Gene
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IDBG-88989 (CRAT)
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Protein Structure
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Function |
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.Isoform 1: Mitochondrion {ECO:0000305}.Isoform 2: Peroxisome {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004092
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carnitine O-acetyltransferase activity
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GO:0005102
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receptor binding
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000542
Acyltransferase ChoActase/COT/CPT
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PFAM |
PF00755
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P43155
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PhosphoSite |
PhosphoSite-P43155
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1384
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UniGene |
Hs.623219
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RefSeq |
NP_001244292
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HUGO |
HGNC:2342
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OMIM |
600184
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CCDS |
CCDS6919
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HPRD |
08971
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IMGT |
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EMBL |
AL158151
BC000723
BT006801
X78706
X79825
X79827
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GenPept |
AAH00723
AAP35447
CAA55359
CAI12869
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