InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DFFA

Summary

InnateDB Protein

IDBP-89049.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DFFA

Protein Name

DNA fragmentation factor, 45kDa, alpha polypeptide

Synonyms

DFF-45; DFF1; ICAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000366237

InnateDB Gene

IDBG-89047 (DFFA)

Protein Structure

UniProt Annotation

Function

Inhibitor of the caspase-activated DNase (DFF40).

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0043065	positive regulation of apoptotic process
GO:0070242	thymocyte apoptotic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902511	negative regulation of apoptotic DNA fragmentation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003508 CIDE-N domain
IPR015121 DNA fragmentation factor 45kDa, middle domain
IPR017299 DNA fragmentation factor, alpha subunit
IPR027296 DNA fragmentation factor 45kDa C-terminal domain

PFAM

PF02017
PF09033

PRINTS

PIRSF

PIRSF037865

SMART

SM00266

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt