InnateDB Protein
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IDBP-89083.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PEX14
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Protein Name
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peroxisomal biogenesis factor 14
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Synonyms
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dJ734G22.2; NAPP2; PBD13A; Pex14p;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349016
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InnateDB Gene
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IDBG-89081 (PEX14)
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Protein Structure
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Function |
Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17.
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Subcellular Localization |
Peroxisome membrane {ECO:0000269PubMed:19197237}; Peripheral membrane protein {ECO:0000269PubMed:19197237}; Cytoplasmic side {ECO:0000269PubMed:19197237}.
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Disease Associations |
Peroxisome biogenesis disorder complementation group K (PBD-CGK) [MIM:614887]: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). Note=The disease is caused by mutations affecting the gene represented in this entry.Peroxisome biogenesis disorder 13A (PBD13A) [MIM:614887]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life. {ECO:0000269PubMed:15146459}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
70
[view]
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Protein-Protein |
70
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006461
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protein complex assembly
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GO:0007031
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peroxisome organization
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GO:0016558
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protein import into peroxisome matrix
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GO:0016560
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protein import into peroxisome matrix, docking
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GO:0016561
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protein import into peroxisome matrix, translocation
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GO:0032091
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negative regulation of protein binding
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GO:0034453
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microtubule anchoring
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GO:0036250
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peroxisome transport along microtubule
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GO:0043433
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negative regulation of sequence-specific DNA binding transcription factor activity
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GO:0044721
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protein import into peroxisome matrix, substrate release
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0051260
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protein homooligomerization
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GO:1901094
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negative regulation of protein homotetramerization
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Cellular Component |
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PDB ID |
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InterPro |
IPR006785
Peroxisome membrane anchor protein Pex14p, N-terminal
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PFAM |
PF04695
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75381
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PhosphoSite |
PhosphoSite-O75381
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TrEMBL |
F5H4J2
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UniProt Splice Variant |
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Entrez Gene |
5195
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UniGene |
Hs.149983
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RefSeq |
NP_004556
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HUGO |
HGNC:8856
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OMIM |
601791
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CCDS |
CCDS30582
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HPRD |
03477
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IMGT |
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EMBL |
AB017546
AF045186
AK002194
AK293684
AK313046
AL139423
AL354956
AL591403
BC006327
CH471130
CR450321
CR542083
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GenPept |
AAC39843
AAH06327
BAA36837
BAG35878
BAG51028
BAH11568
CAD20149
CAG29317
CAG46880
CAH70044
CAI19198
EAW71661
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