InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRRX2

Summary

InnateDB Protein

IDBP-89218.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRRX2

Protein Name

paired related homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361547

InnateDB Gene

IDBG-89216 (PRRX2)

Protein Structure

UniProt Annotation

Function

May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. {ECO:0000269PubMed:9665387}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00138}.

Disease Associations

Tissue Specificity

In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis. {ECO:0000269PubMed:9665387}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0030326	embryonic limb morphogenesis
GO:0042472	inner ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0045880	positive regulation of smoothened signaling pathway
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048844	artery morphogenesis
GO:0051216	cartilage development