InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMNDC1

Summary

InnateDB Protein

IDBP-89335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMNDC1

Protein Name

survival motor neuron domain containing 1

Synonyms

SMNR; SPF30; TDRD16C;

Species

Homo sapiens

Ensembl Protein

ENSP00000358616

InnateDB Gene

IDBG-89333 (SMNDC1)

Protein Structure

UniProt Annotation

Function

Necessary for spliceosome assembly. Overexpression causes apoptosis. {ECO:0000269PubMed:11331295, ECO:0000269PubMed:11331595, ECO:0000269PubMed:9817934}.

Subcellular Localization

Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.

Disease Associations

Tissue Specificity

Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas. {ECO:0000269PubMed:9817934}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0006397	mRNA processing
GO:0006915	apoptotic process
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0045111	intermediate filament cytoskeleton