Version 5.4
Homo sapiens Protein: PTCHD2
Summary
InnateDB Protein IDBP-89367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTCHD2
Protein Name patched domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000294484
InnateDB Gene IDBG-89363 (PTCHD2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in brain and testis. {ECO:0000269PubMed:15645143}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008158 hedgehog receptor activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0032368 regulation of lipid transport
GO:0042632 cholesterol homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR000731 Sterol-sensing domain
IPR003392 Patched
IPR004869 Membrane transport protein, MMPL domain
PFAM PF02460
PF03176
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2K9
PhosphoSite PhosphoSite-Q9P2K9
TrEMBL
UniProt Splice Variant
Entrez Gene 57540
UniGene Hs.202355
RefSeq NP_065831
HUGO HGNC:29251
OMIM 611251
CCDS CCDS41247
HPRD
IMGT
EMBL AB037758 AL031735 AL117236 AL590989
GenPept BAA92575 CAB55303 CAH70606 CAI22474

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca