InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP5

Summary

InnateDB Protein

IDBP-89385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP5

Protein Name

dual specificity phosphatase 5

Synonyms

DUSP; HVH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000358596

InnateDB Gene

IDBG-89383 (DUSP5)

Protein Structure

UniProt Annotation

Function

Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001706	endoderm formation
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF00581

PRINTS

PR00700
PR01764

PIRSF

PIRSF000939

SMART

SM00194
SM00450
SM00404
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References