InnateDB Protein
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IDBP-89567.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DRAXIN
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Protein Name
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chromosome 1 open reading frame 187
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000294485
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InnateDB Gene
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IDBG-89565 (DRAXIN)
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Protein Structure
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Function |
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255HAMAP- Rule:MF_03060}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NBI3
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PhosphoSite |
PhosphoSite-Q8NBI3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
374946
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UniGene |
Hs.733197
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RefSeq |
NP_940947
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HUGO |
HGNC:25054
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OMIM |
612682
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CCDS |
CCDS135
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HPRD |
11844
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IMGT |
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EMBL |
AB301919
AK075558
AL031731
AL953897
AY358750
BC111064
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GenPept |
AAI11065
AAQ89110
BAC11697
BAG80561
CAI15884
CAI20222
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