InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AARS2

Summary

InnateDB Protein

IDBP-89595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AARS2

Protein Name

alanyl-tRNA synthetase 2, mitochondrial (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000244571

InnateDB Gene

IDBG-89593 (AARS2)

Protein Structure

UniProt Annotation

Function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255HAMAP-Rule:MF_03133}.

Subcellular Localization

Mitochondrion {ECO:0000255HAMAP- Rule:MF_03133, ECO:0000269PubMed:21549344}.

Disease Associations

Combined oxidative phosphorylation deficiency 8 (COXPD8) [MIM:614096]: A mitochondrial disease characterized by a lethal infantile hypertrophic cardiomyopathy, generalized muscle dysfunction and some neurologic involvement. The liver is not affected. {ECO:0000269PubMed:21549344}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004813	alanine-tRNA ligase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006419	alanyl-tRNA aminoacylation
GO:0010467	gene expression
GO:0033108	mitochondrial respiratory chain complex assembly
GO:0043039	tRNA aminoacylation
GO:0070143	mitochondrial alanyl-tRNA aminoacylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR002318 Alanine-tRNA ligase, class IIc
IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
IPR018165 Alanyl-tRNA synthetase, class IIc, core domain

PFAM

PF07973
PF01411

PRINTS

PR00980

PIRSF

SMART

SM00863

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt