Version 5.4
Homo sapiens Protein: MTHFR
Summary
InnateDB Protein IDBP-89661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTHFR
Protein Name methylenetetrahydrofolate reductase (NAD(P)H)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365770
InnateDB Gene IDBG-89655 (MTHFR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity
GO:0072341 modified amino acid binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006555 methionine metabolic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0008015 blood circulation
GO:0035999 tetrahydrofolate interconversion
GO:0044281 small molecule metabolic process
GO:0046655 folic acid metabolic process
GO:0050667 homocysteine metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003171 Methylenetetrahydrofolate reductase
IPR004621 Eukaryotic-type methylenetetrahydrofolate reductase
IPR029041 FAD-linked oxidoreductase-like
PFAM PF02219
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9NY63
UniProt Splice Variant
Entrez Gene 4524
UniGene Hs.737916
RefSeq XP_005263515
HUGO HGNC:7436
OMIM 607093
CCDS
HPRD 06158
IMGT
EMBL AF105977 AF105978 AF105979 AF105980 AF105981 AF105982 AF105983 AF105984 AF105985 AF105986 AF105987 AF398930 AJ237672 AJ249275 AK312907 AL953897 AY046560 AY046561 AY046562 AY046563 AY046564 AY046565 AY338232 BC053509 CH471130 JQ429447 U09806
GenPept AAA74440 AAD17965 AAH53509 AAL17646 AAL17647 AAL17648 AAL17649 AAL17650 AAL17651 AAN40864 AAN40865 AAP88033 AFQ62002 BAG35753 CAB41971 CAB81551 CAI15885 EAW71709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca