Version 5.4
Homo sapiens Protein: QRFP
Summary
InnateDB Protein IDBP-89666.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QRFP
Protein Name pyroglutamylated RFamide peptide
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000345487
InnateDB Gene IDBG-89664 (QRFP)
Protein Structure
UniProt Annotation
Function Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid. {ECO:0000269PubMed:12714592}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0031854 orexigenic neuropeptide QRFP receptor binding
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007626 locomotory behavior
GO:0045777 positive regulation of blood pressure
GO:0060259 regulation of feeding behavior
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR024565 Orexigenic neuropeptide QRFP/P518
PFAM PF11109
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P83859
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 347148
UniGene
RefSeq NP_937823
HUGO HGNC:29982
OMIM 609795
CCDS CCDS6936
HPRD 17813
IMGT
EMBL AB109625 AL161733 AY438326 BC101127
GenPept AAI01128 AAR24354 BAC98934 CAM45757

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca