Version 5.4
Homo sapiens Protein: AIF1L
Summary
InnateDB Protein IDBP-89744.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIF1L
Protein Name allograft inflammatory factor 1-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361374
InnateDB Gene IDBG-89728 (AIF1L)
Protein Structure
UniProt Annotation
Function Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. {ECO:0000269PubMed:18699778}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:18699778}. Cell projection, ruffle membrane {ECO:0000269PubMed:18699778}; Peripheral membrane protein {ECO:0000269PubMed:18699778}; Cytoplasmic side {ECO:0000269PubMed:18699778}. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0051015 actin filament binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQI0
PhosphoSite PhosphoSite-Q9BQI0
TrEMBL Q5JUP1
UniProt Splice Variant
Entrez Gene 83543
UniGene Hs.4944
RefSeq NP_001172025
HUGO HGNC:28904
OMIM
CCDS CCDS55349
HPRD 12967
IMGT
EMBL AK022845 AK091912 AK128526 AK314600 AL136566 AL157938 AL833896 AY359067 BC021253 CH471090
GenPept AAH21253 AAQ89426 BAB14269 BAC03770 BAC87480 BAG37171 CAB66501 CAD38752 CAI41102 CAI41103 CAI41104 EAW87958

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca