InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLIC5

Summary

InnateDB Protein

IDBP-89805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIC5

Protein Name

chloride intracellular channel 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000185206

InnateDB Gene

IDBG-89803 (CLIC5)

Protein Structure

UniProt Annotation

Function

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. {ECO:0000250, ECO:0000269PubMed:15184393, ECO:0000269PubMed:18028448, ECO:0000269PubMed:20335315}.

Subcellular Localization

Isoform 1: Cytoplasm, cell cortex {ECO:0000269PubMed:15184393}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15184393}. Membrane {ECO:0000269PubMed:15184393}; Single-pass membrane protein {ECO:0000269PubMed:15184393}. Note=Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.Isoform 2: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Single-pass membrane protein. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Colocalized with podocalyxin in renal glomeruli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level). {ECO:0000269PubMed:20335315}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0002021	response to dietary excess
GO:0002024	diet induced thermogenesis
GO:0006810	transport
GO:0006821	chloride transport
GO:0007565	female pregnancy
GO:0007605	sensory perception of sound
GO:0008104	protein localization
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0050885	neuromuscular process controlling balance
GO:0060088	auditory receptor cell stereocilium organization
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0032420	stereocilium
GO:0032421	stereocilium bundle
GO:0034707	chloride channel complex
GO:0070062	extracellular vesicular exosome