InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENPP4

Summary

InnateDB Protein

IDBP-89823.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP4

Protein Name

ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)

Synonyms

NPP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000318066

InnateDB Gene

IDBG-89819 (ENPP4)

Protein Structure

UniProt Annotation

Function

Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269PubMed:22995898, ECO:0000269PubMed:24338010}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269PubMed:22995898}.

Disease Associations

Tissue Specificity

Expressed on the surface of vascular endothelia. {ECO:0000269PubMed:22995898}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008484	sulfuric ester hydrolase activity
GO:0046872	metal ion binding
GO:0047710	bis(5'-adenosyl)-triphosphatase activity

Biological Process

GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0030194	positive regulation of blood coagulation
GO:0046130	purine ribonucleoside catabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000917 Sulfatase
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain

PFAM

PF00884
PF01663

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y6X5

PhosphoSite