Version 5.4
Homo sapiens Protein: ZDHHC6
Summary
InnateDB Protein IDBP-89831.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZDHHC6
Protein Name zinc finger, DHHC-type containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358413
InnateDB Gene IDBG-89829 (ZDHHC6)
Protein Structure
UniProt Annotation
Function Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. {ECO:0000269PubMed:22314232}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:22314232}; Multi-pass membrane protein {ECO:0000269PubMed:22314232}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
Biological Process
GO:0018345 protein palmitoylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF01529
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H6R6
PhosphoSite PhosphoSite-Q9H6R6
TrEMBL
UniProt Splice Variant
Entrez Gene 64429
UniGene
RefSeq NP_071939
HUGO HGNC:19160
OMIM
CCDS CCDS7574
HPRD 15721
IMGT
EMBL AF267740 AK025605 AK026369 AK223086 BC007213 BC017434 CH471066
GenPept AAH07213 AAH17434 AAL56663 BAB15187 BAB15462 BAD96806 EAW49526 EAW49528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca