Version 5.4
Homo sapiens Protein: PPAPDC3
Summary
InnateDB Protein IDBP-89932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAPDC3
Protein Name phosphatidic acid phosphatase type 2 domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361338
InnateDB Gene IDBG-89930 (PPAPDC3)
Protein Structure
UniProt Annotation
Function Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0010832 negative regulation of myotube differentiation
Cellular Component
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBV4
PhosphoSite PhosphoSite-Q8NBV4
TrEMBL
UniProt Splice Variant
Entrez Gene 84814
UniGene Hs.134292
RefSeq NP_116117
HUGO HGNC:28174
OMIM
CCDS CCDS6942
HPRD 12972
IMGT
EMBL AK027568 AK075207 AL354855 BC006362
GenPept AAH06362 BAB55204 BAC11472 CAI16274 CAI16275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca