Version 5.4
Homo sapiens Protein: TDRD6
Summary
InnateDB Protein IDBP-89944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDRD6
Protein Name tudor domain containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346065
InnateDB Gene IDBG-89942 (TDRD6)
Protein Structure
UniProt Annotation
Function Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007281 germ cell development
GO:0007283 spermatogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0030529 ribonucleoprotein complex
GO:0033391 chromatoid body
GO:0043186 P granule
Protein Structure and Domains
PDB ID
InterPro IPR002999 Tudor domain
PFAM PF00567
PRINTS
PIRSF
SMART SM00333
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60522
PhosphoSite PhosphoSite-O60522
TrEMBL
UniProt Splice Variant
Entrez Gene 221400
UniGene Hs.656983
RefSeq NP_001010870
HUGO HGNC:21339
OMIM 611200
CCDS CCDS34470
HPRD 18172
IMGT
EMBL AF039442 AK125838 AK131455 AL591242 BX648686
GenPept AAC18034 BAG54254 CAH73905 CAI45997

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca