InnateDB Protein
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IDBP-89958.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLA2G7
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Protein Name
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phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
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Synonyms
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LDL-PLA2; LP-PLA2; PAFAD; PAFAH;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000274793
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InnateDB Gene
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IDBG-89956 (PLA2G7)
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Protein Structure
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Function |
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
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Subcellular Localization |
Secreted, extracellular space.
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Disease Associations |
Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms. {ECO:0000269PubMed:8675689, ECO:0000269PubMed:9245731, ECO:0000269PubMed:9412624, ECO:0000269PubMed:9472966, ECO:0000269PubMed:9759612}. Note=The disease is caused by mutations affecting the gene represented in this entry.Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269PubMed:10733466}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003847
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1-alkyl-2-acetylglycerophosphocholine esterase activity
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GO:0005543
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phospholipid binding
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GO:0047499
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calcium-independent phospholipase A2 activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005065
Platelet-activating factor acetylhydrolase
IPR016715
Platelet-activating factor acetylhydrolase, eucaryote
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF03403
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PRINTS |
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PIRSF |
PIRSF018169
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13093
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PhosphoSite |
PhosphoSite-Q13093
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7941
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UniGene |
Hs.584823
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RefSeq |
NP_005075
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HUGO |
HGNC:9040
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OMIM |
601690
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CCDS |
CCDS4917
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HPRD |
03407
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IMGT |
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EMBL |
AL591242
BC038452
CH471081
EF568110
U20157
U24577
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GenPept |
AAB04170
AAC50126
AAH38452
ABQ01234
CAH73907
EAX04301
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