Version 5.4
Homo sapiens Protein: NRAP
Summary
InnateDB Protein IDBP-89986.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRAP
Protein Name nebulin-related anchoring protein
Synonyms N-RAP;
Species Homo sapiens
Ensembl Protein ENSP00000358367
InnateDB Gene IDBG-89984 (NRAP)
Protein Structure
UniProt Annotation
Function May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250UniProtKB:Q80XB4}.
Subcellular Localization Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. {ECO:0000269PubMed:12789664}.
Disease Associations
Tissue Specificity Expressed in cardiac and skeletal muscle. {ECO:0000269PubMed:12789664}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008270 zinc ion binding
GO:0051371 muscle alpha-actinin binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005916 fascia adherens
GO:0005927 muscle tendon junction
Protein Structure and Domains
PDB ID
InterPro IPR000900 Nebulin repeat
IPR001781 Zinc finger, LIM-type
IPR013998 Nebulin
PFAM PF00880
PF00412
PRINTS PR00510
PIRSF
SMART SM00227
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VF7
PhosphoSite PhosphoSite-Q86VF7
TrEMBL
UniProt Splice Variant
Entrez Gene 4892
UniGene Hs.268788
RefSeq
HUGO HGNC:7988
OMIM 602873
CCDS
HPRD 04189
IMGT
EMBL AF542553 AK056969 AK096886 AL390197 AL831980 AL832025 AL832330 AL832457 AY081943 AY177620 AY177621 BC058825 BC070130 BX640682 BX640730 BX641052 U96486
GenPept AAC51786 AAH58825 AAH70130 AAL99185 AAO47073 AAO47074 AAQ09536 BAB71328 BAC04884 CAD38623 CAD89899 CAD89910 CAD89998 CAE45811 CAE45846 CAE46027 CAH71110 CAH71111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca