Version 5.4
Homo sapiens Protein: GPR116
Summary
InnateDB Protein IDBP-90019.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR116
Protein Name G protein-coupled receptor 116
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000283296
InnateDB Gene IDBG-90015 (GPR116)
Protein Structure
UniProt Annotation
Function May have a role in the regulation of acid-base balance. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0019216 regulation of lipid metabolic process
GO:0042593 glucose homeostasis
GO:0043129 surfactant homeostasis
GO:0045444 fat cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000082 SEA domain
IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008078 GPCR, family 2, Ig-hepta receptor
IPR013098 Immunoglobulin I-set
IPR017981 GPCR, family 2-like
PFAM PF01390
PF01825
PF00002
PF07679
PRINTS PR00249
PR01695
PIRSF
SMART SM00200
SM00303
SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZF2
PhosphoSite PhosphoSite-Q8IZF2
TrEMBL E9PBS6
UniProt Splice Variant
Entrez Gene 221395
UniGene Hs.711314
RefSeq NP_001091988
HUGO HGNC:19030
OMIM
CCDS CCDS4919
HPRD 11010
IMGT
EMBL AB018301 AL050295 AL096772 AL832125 AY140958 AY255552 AY498875 BC066121
GenPept AAH66121 AAN46672 AAO85064 AAS21061 BAA34478 CAB43394 CAB61578

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca