Version 5.4
Homo sapiens Protein: MIIP
Summary
InnateDB Protein IDBP-90037.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIIP
Protein Name migration and invasion inhibitory protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000235332
InnateDB Gene IDBG-90035 (MIIP)
Protein Structure
UniProt Annotation
Function Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269PubMed:14617774}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. {ECO:0000269PubMed:14617774}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JXC2
PhosphoSite PhosphoSite-Q5JXC2
TrEMBL
UniProt Splice Variant
Entrez Gene 60672
UniGene Hs.8595
RefSeq NP_068752
HUGO HGNC:25715
OMIM 608772
CCDS CCDS143
HPRD 07768
IMGT
EMBL AK022500 AK024020 AL096840 BC008068 CH471130 FJ618905
GenPept AAH08068 ACM90320 BAB14062 BAB14781 CAI19089 EAW71729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca