InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPQ

Summary

InnateDB Protein

IDBP-90178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPQ

Protein Name

centromere protein Q

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000337289

InnateDB Gene

IDBG-90176 (CENPQ)

Protein Structure

UniProt Annotation

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269PubMed:16622420}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16622420}. Chromosome, centromere {ECO:0000269PubMed:16622420}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000278	mitotic cell cycle
GO:0006334	nucleosome assembly
GO:0034080	centromere-specific nucleosome assembly

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0045111	intermediate filament cytoskeleton