InnateDB Protein
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IDBP-90194.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DCLRE1A
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Protein Name
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DNA cross-link repair 1A
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Synonyms
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PSO2; SNM1; SNM1A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358311
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InnateDB Gene
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IDBG-90190 (DCLRE1A)
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Protein Structure
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Function |
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269PubMed:15542852}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10848582, ECO:0000269PubMed:12446782, ECO:0000269PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:12446782}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001279
Beta-lactamase-like
IPR011084
DNA repair metallo-beta-lactamase
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PFAM |
PF00753
PF07522
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PRINTS |
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PIRSF |
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SMART |
SM00849
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PJP8
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PhosphoSite |
PhosphoSite-Q6PJP8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9937
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UniGene |
Hs.712962
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RefSeq |
NP_001258745
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HUGO |
HGNC:17660
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OMIM |
609682
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CCDS |
CCDS7584
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HPRD |
08519
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IMGT |
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EMBL |
AL592546
AY607842
BC013124
BC062582
CH471066
D42045
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GenPept |
AAH13124
AAH62582
AAT09762
BAA07646
CAI12637
EAW49489
EAW49490
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