InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRB1

Summary

InnateDB Protein

IDBP-90235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB1

Protein Name

adrenergic, beta-1-, receptor

Synonyms

ADRB1R; B1AR; BETA1AR; RHR;

Species

Homo sapiens

Ensembl Protein

ENSP00000358301

InnateDB Gene

IDBG-90231 (ADRB1)

Protein Structure

UniProt Annotation

Function

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269PubMed:12391161}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004939	beta-adrenergic receptor activity
GO:0004940	beta1-adrenergic receptor activity
GO:0005057	receptor signaling protein activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030165	PDZ domain binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0035240	dopamine binding
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0003061	positive regulation of the force of heart contraction by norepinephrine
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0005980	glycogen catabolic process
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007266	Rho protein signal transduction
GO:0007568	aging
GO:0007613	memory
GO:0009409	response to cold
GO:0010460	positive regulation of heart rate
GO:0019233	sensory perception of pain
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031649	heat generation
GO:0032320	positive regulation of Ras GTPase activity
GO:0033365	protein localization to organelle
GO:0035811	negative regulation of urine volume
GO:0040015	negative regulation of multicellular organism growth
GO:0042060	wound healing
GO:0042596	fear response
GO:0043065	positive regulation of apoptotic process
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045986	negative regulation of smooth muscle contraction
GO:0046878	positive regulation of saliva secretion
GO:0050873	brown fat cell differentiation
GO:0051924	regulation of calcium ion transport
GO:0055088	lipid homeostasis
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0086004	regulation of cardiac muscle cell contraction
GO:1900135	positive regulation of renin secretion into blood stream
GO:2001259	positive regulation of cation channel activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000507 Beta 1 adrenoceptor
IPR002232 5-Hydroxytryptamine 6 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00561
PR01102
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08588