Version 5.4
Homo sapiens Protein: L3MBTL2
Summary
InnateDB Protein IDBP-9031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol L3MBTL2
Protein Name l(3)mbt-like 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216237
InnateDB Gene IDBG-9029 (L3MBTL2)
Protein Structure
UniProt Annotation
Function Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269PubMed:19233876}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
GO:0042393 histone binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR004092 Mbt repeat
IPR012313 Zinc finger, FCS-type
PFAM PF02820
PRINTS
PIRSF
SMART SM00561
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969R5
PhosphoSite PhosphoSite-Q969R5
TrEMBL
UniProt Splice Variant
Entrez Gene 83746
UniGene Hs.517641
RefSeq NP_113676
HUGO HGNC:18594
OMIM 611865
CCDS CCDS14011
HPRD 13954
IMGT
EMBL AJ305226 AJ305227 AK074091 AK097052 AL035658 AL035681 AL136564 BC017191 CR456482
GenPept AAH17191 BAB84917 BAC04936 CAB66499 CAC37794 CAC37795 CAG30368 CAI22654 CAI23036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca