Version 5.4
Homo sapiens Protein: DEFB114
Summary
InnateDB Protein IDBP-90354.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFB114
Protein Name defensin, beta 114
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312702
InnateDB Gene IDBG-90352 (DEFB114)
Protein Structure
UniProt Annotation
Function Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS- induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. {ECO:0000269PubMed:23482568}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in epididymis, predominantly in the caput (at protein level). {ECO:0000269PubMed:23482568}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
Biological Process
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q30KQ6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 245928
UniGene Hs.381372
RefSeq NP_001032588
HUGO HGNC:18095
OMIM 615243
CCDS CCDS34474
HPRD 18758
IMGT
EMBL AY122470 DQ012018
GenPept AAM93912 AAY59754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca