InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TELO2

Summary

InnateDB Protein

IDBP-9037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TELO2

Protein Name

TEL2, telomere maintenance 2, homolog (S. cerevisiae)

Synonyms

CLK2; TEL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262319

InnateDB Gene

IDBG-9035 (TELO2)

Protein Structure

UniProt Annotation

Function

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269PubMed:12670948, ECO:0000269PubMed:20810650}.

Subcellular Localization

Cytoplasm. Membrane. Nucleus. Chromosome, telomere {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0032947	protein complex scaffold

Biological Process

GO:0032006

regulation of TOR signaling

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031931	TORC1 complex
GO:0031932	TORC2 complex