InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AVPR2

Summary

InnateDB Protein

IDBP-90516.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AVPR2

Protein Name

arginine vasopressin receptor 2

Synonyms

ADHR; DI1; DIR; DIR3; NDI; V2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000359066

InnateDB Gene

IDBG-90510 (AVPR2)

Protein Structure

UniProt Annotation

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269PubMed:19440390}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]: Characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. {ECO:0000269PubMed:15872203}. Note=The disease is caused by mutations affecting the gene represented in this entry.Diabetes insipidus, nephrogenic, X-linked (XNDI) [MIM:304800]: A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. {ECO:0000269PubMed:10694923, ECO:0000269PubMed:10770218, ECO:0000269PubMed:11232028, ECO:0000269PubMed:11916004, ECO:0000269PubMed:1303257, ECO:0000269PubMed:1303271, ECO:0000269PubMed:1356229, ECO:0000269PubMed:16845277, ECO:0000269PubMed:7560098, ECO:0000269PubMed:7833930, ECO:0000269PubMed:7984150, ECO:0000269PubMed:7987330, ECO:0000269PubMed:7999078, ECO:0000269PubMed:8037205, ECO:0000269PubMed:8045948, ECO:0000269PubMed:8078903, ECO:0000269PubMed:8267567, ECO:0000269PubMed:8479490, ECO:0000269PubMed:8514744, ECO:0000269PubMed:9402087, ECO:0000269PubMed:9452109, ECO:0000269PubMed:9711877}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006833	water transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007588	excretion
GO:0007599	hemostasis
GO:0010628	positive regulation of gene expression
GO:0031398	positive regulation of protein ubiquitination
GO:0055085	transmembrane transport

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000161 Vasopressin V2 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001817 Vasopressin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00898
PR00237
PR00896

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30518