InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL17F

Summary

InnateDB Protein

IDBP-90521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17F

Protein Name

interleukin 17F

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000337432

InnateDB Gene

IDBG-90517 (IL17F)

Protein Structure

UniProt Annotation

Function

Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.

Subcellular Localization

Secreted.

Disease Associations

Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006029	proteoglycan metabolic process
GO:0006954	inflammatory response
GO:0016525	negative regulation of angiogenesis
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0042089	cytokine biosynthetic process
GO:0042109	lymphotoxin A biosynthetic process
GO:0045076	regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0045414	regulation of interleukin-8 biosynthetic process
GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:1900017	positive regulation of cytokine production involved in inflammatory response