InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRRC38

Summary

InnateDB Protein

IDBP-90571.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRC38

Protein Name

leucine rich repeat containing 38

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365253

InnateDB Gene

IDBG-90569 (LRRC38)

Protein Structure

UniProt Annotation

Function

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. {ECO:0000269PubMed:22547800}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in adrenal gland, thymus and skeletal muscle. {ECO:0000269PubMed:22547800}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006811

ion transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01462
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00013
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VT99