InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP4

Summary

InnateDB Protein

IDBP-90577.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP4

Protein Name

Rho GTPase activating protein 4

Synonyms

C1; p115; RGC1; RhoGAP4; SrGAP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000359045

InnateDB Gene

IDBG-90575 (ARHGAP4)

Protein Structure

UniProt Annotation

Function

Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

Subcellular Localization

Cytoplasm. Note=Just below the plasma membrane.

Disease Associations

Tissue Specificity

Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007399	nervous system development
GO:0009967	positive regulation of signal transduction
GO:0010764	negative regulation of fibroblast migration
GO:0030517	negative regulation of axon extension
GO:0032321	positive regulation of Rho GTPase activity
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001060 FCH domain
IPR001452 SH3 domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain

PFAM

PF00620
PF00611
PF00018
PF14604
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00055
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt