InnateDB Protein
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IDBP-90588.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDPN
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Protein Name
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podoplanin
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Synonyms
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AGGRUS; GP36; Gp38; GP40; HT1A-1; OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000294489
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InnateDB Gene
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IDBG-90582 (PDPN)
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Protein Structure
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Function |
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. {ECO:0000250UniProtKB:Q62011, ECO:0000269PubMed:14522983, ECO:0000269PubMed:15231832, ECO:0000269PubMed:15515019, ECO:0000269PubMed:9651190}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. {ECO:0000269PubMed:10393083, ECO:0000269PubMed:14522983, ECO:0000269PubMed:15515019}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008783
Podoplanin
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PFAM |
PF05808
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86YL7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
H0YA72
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UniProt Splice Variant |
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Entrez Gene |
10630
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UniGene |
Hs.468675
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RefSeq |
XP_006710358
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HUGO |
HGNC:29602
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OMIM |
608863
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CCDS |
CCDS30602
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HPRD |
16398
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IMGT |
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EMBL |
AB127958
AF030427
AF030428
AF390106
AJ225022
AK075327
AK075345
AK312607
AL354712
AL359771
AY194238
BC014668
BC022812
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GenPept |
AAD01899
AAD01900
AAH14668
AAH22812
AAM73655
AAO22143
BAC11550
BAC11557
BAD04046
BAG35495
CAA12352
CAI17983
CAI17984
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