Version 5.4
Homo sapiens Protein: TRAM2
Summary
InnateDB Protein IDBP-90678.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAM2
Protein Name translocation associated membrane protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000182527
InnateDB Gene IDBG-90676 (TRAM2)
Protein Structure
UniProt Annotation
Function Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. {ECO:0000269PubMed:14749390}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0032964 collagen biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006634 TRAM/LAG1/CLN8 homology domain
IPR013599 TRAM1-like protein
IPR016447 Translocation associated membrane protein
PFAM PF03798
PF08390
PRINTS
PIRSF PIRSF005449
SMART SM00724
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15035
PhosphoSite PhosphoSite-Q15035
TrEMBL G1UI27
UniProt Splice Variant
Entrez Gene 9697
UniGene Hs.607554
RefSeq NP_036420
HUGO HGNC:16855
OMIM 608485
CCDS CCDS34477
HPRD 16338
IMGT
EMBL AB621814 AK291751 AL049611 BC028121 CH471081 D31762
GenPept AAH28121 BAA06540 BAF84440 BAK64150 CAB71119 EAX04373 EAX04375

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca