InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIAA1598

Summary

InnateDB Protein

IDBP-90751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIAA1598

Protein Name

KIAA1598

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347532

InnateDB Gene

IDBG-90749 (KIAA1598)

Protein Structure

UniProt Annotation

Function

Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, axon {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007411	axon guidance
GO:2000114	regulation of establishment of cell polarity
GO:2001222	regulation of neuron migration