InnateDB Protein
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IDBP-90753.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIAA1598
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Protein Name
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KIAA1598
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000260777
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InnateDB Gene
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IDBG-90749 (KIAA1598)
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Protein Structure
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Function |
Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell projection, axon {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013992
Adenylate cyclase-associated CAP, N-terminal
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PFAM |
PF01213
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A0MZ66
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PhosphoSite |
PhosphoSite-A0MZ66
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57698
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UniGene |
Hs.700097
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RefSeq |
NP_001245227
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HUGO |
HGNC:29319
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OMIM |
611171
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CCDS |
CCDS73207
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HPRD |
11155
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IMGT |
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EMBL |
AB046818
AC012308
AC023283
AK001984
AK091381
AK091578
AK095419
AK095703
AK095709
AK302705
AK304865
AL731557
BC022348
BC032303
CH471066
CR749417
EF055487
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GenPept |
AAH22348
AAH32303
ABK56022
BAA92019
BAB13424
BAG52345
BAG52384
BAG53052
BAG53109
BAG53110
BAG65603
BAH13785
CAH18259
EAW49434
EAW49438
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