InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC18A2

Summary

InnateDB Protein

IDBP-90797.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC18A2

Protein Name

solute carrier family 18 (vesicular monoamine), member 2

Synonyms

SVAT; SVMT; VAT2; VMAT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000298472

InnateDB Gene

IDBG-90795 (SLC18A2)

Protein Structure

UniProt Annotation

Function

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Subcellular Localization

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005275	amine transmembrane transporter activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008504	monoamine transmembrane transporter activity
GO:0015222	serotonin transmembrane transporter activity
GO:0019899	enzyme binding
GO:0022857	transmembrane transporter activity
GO:0031072	heat shock protein binding

Biological Process

GO:0001975	response to amphetamine
GO:0006836	neurotransmitter transport
GO:0006837	serotonin transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007568	aging
GO:0007626	locomotory behavior
GO:0009635	response to herbicide
GO:0009636	response to toxic substance
GO:0009791	post-embryonic development
GO:0010038	response to metal ion
GO:0010043	response to zinc ion
GO:0015844	monoamine transport
GO:0016265	death
GO:0030073	insulin secretion
GO:0032456	endocytic recycling
GO:0035690	cellular response to drug
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0042594	response to starvation
GO:0051412	response to corticosterone
GO:0051589	negative regulation of neurotransmitter transport
GO:0055085	transmembrane transport
GO:0071242	cellular response to ammonium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043679	axon terminus
GO:0044297	cell body
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q05940

PhosphoSite