Version 5.4
Homo sapiens Protein: EFHD2
Summary
InnateDB Protein IDBP-90800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFHD2
Protein Name EF-hand domain family, member D2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365147
InnateDB Gene IDBG-90798 (EFHD2)
Protein Structure
UniProt Annotation
Function May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}.
Subcellular Localization Membrane raft {ECO:0000250}. Note=In a mouse immature B-cell line WEHI-231. {ECO:0000250}.
Disease Associations
Tissue Specificity Found in lymphocytes; preferentially expressed in CD8+ cells. {ECO:0000269PubMed:11788997, ECO:0000269PubMed:15274114}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96C19
PhosphoSite PhosphoSite-Q96C19
TrEMBL A0A024QZ77
UniProt Splice Variant
Entrez Gene 79180
UniGene Hs.465374
RefSeq NP_077305
HUGO HGNC:28670
OMIM
CCDS CCDS155
HPRD 13266
IMGT
EMBL AL031283 BC007233 BC014923 BC023611 BC068473 CH471167
GenPept AAH07233 AAH14923 AAH23611 AAH68473 CAI21431 EAW51720 EAW51723

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca