Version 5.4
Homo sapiens Protein: PDZD8
Summary
InnateDB Protein IDBP-90817.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDZD8
Protein Name PDZ domain containing 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000334642
InnateDB Gene IDBG-90815 (PDZD8)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage. May promote retroviral infection. {ECO:0000269PubMed:20573829, ECO:0000269PubMed:21549406, ECO:0000269PubMed:21834987}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0016032 viral process
GO:0022604 regulation of cell morphogenesis
GO:0035556 intracellular signal transduction
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
PFAM PF00595
PF13180
PF00130
PRINTS
PIRSF
SMART SM00228
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEN9
PhosphoSite PhosphoSite-Q8NEN9
TrEMBL
UniProt Splice Variant
Entrez Gene 118987
UniGene Hs.501149
RefSeq NP_776152
HUGO HGNC:26974
OMIM 614235
CCDS CCDS7600
HPRD 11423
IMGT
EMBL AL122051 AL359836 AL391988 AY211924 AY211929 BC028375
GenPept AAH28375 AAO65177 AAO65182 CAB59184 CAH70347 CAH73253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca