InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB11FIP2

Summary

InnateDB Protein

IDBP-90858.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB11FIP2

Protein Name

RAB11 family interacting protein 2 (class I)

Synonyms

nRip11; Rab11-FIP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000347839

InnateDB Gene

IDBG-90852 (RAB11FIP2)

Protein Structure

UniProt Annotation

Function

A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269PubMed:12364336, ECO:0000269PubMed:15304524, ECO:0000269PubMed:16251358, ECO:0000269PubMed:16775013, ECO:0000269PubMed:19542231}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006833	water transport
GO:0015031	protein transport
GO:0030010	establishment of cell polarity
GO:0035773	insulin secretion involved in cellular response to glucose stimulus
GO:0045055	regulated secretory pathway
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0055038	recycling endosome membrane