InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTA4

Summary

InnateDB Protein

IDBP-90865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTA4

Protein Name

glutathione S-transferase alpha 4

Synonyms

GSTA4-4; GTA4;

Species

Homo sapiens

Ensembl Protein

ENSP00000359998

InnateDB Gene

IDBG-90859 (GSTA4)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). {ECO:0000269PubMed:10329152, ECO:0000269PubMed:20085333}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0044281	small molecule metabolic process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003080 Glutathione S-transferase, alpha class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM