InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXO9

Summary

InnateDB Protein

IDBP-90956.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO9

Protein Name

F-box protein 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326968

InnateDB Gene

IDBG-90954 (FBXO9)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269PubMed:23263282}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23263282}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032006	regulation of TOR signaling