InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TKTL1

Summary

InnateDB Protein

IDBP-90972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TKTL1

Protein Name

transketolase-like 1

Synonyms

TKR; TKT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000358931

InnateDB Gene

IDBG-90970 (TKTL1)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear.

Disease Associations

Tissue Specificity

Expressed in fetal and adult heart, brain, lung, liver, and kidney, and in adult placenta, skeletal muscle and pancreas. Up-regulated in various epithelial tumors. {ECO:0000269PubMed:15991799, ECO:0000269PubMed:16465194, ECO:0000269PubMed:16969476, ECO:0000269PubMed:8838793}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004802	transketolase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0006007	glucose catabolic process
GO:0006772	thiamine metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001017 Dehydrogenase, E1 component
IPR005474 Transketolase, N-terminal
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676
PF00456
PF02779
PF02780

PRINTS

PIRSF

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51854