InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RSC1A1

Summary

InnateDB Protein

IDBP-91040.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RSC1A1

Protein Name

regulatory solute carrier protein, family 1, member 1

Synonyms

RS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000341963

InnateDB Gene

IDBG-227458 (RSC1A1)

Protein Structure

UniProt Annotation

Function

Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269PubMed:14724758, ECO:0000269PubMed:16788146, ECO:0000269PubMed:8836035}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16788147}. Nucleus {ECO:0000269PubMed:16788147}. Golgi apparatus, trans- Golgi network {ECO:0000269PubMed:16788147}. Note=Localizes at the inner side of the plasma membrane.

Disease Associations

Tissue Specificity

Expressed in small intestine, kidney and brain. {ECO:0000269PubMed:8836035}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008200	ion channel inhibitor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0050892	intestinal absorption
GO:0051051	negative regulation of transport

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0030054	cell junction
GO:0043231	intracellular membrane-bounded organelle