Version 5.4
Homo sapiens Protein: FERD3L
Summary
InnateDB Protein IDBP-9125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FERD3L
Protein Name Fer3-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000275461
InnateDB Gene IDBG-9123 (FERD3L)
Protein Structure
UniProt Annotation
Function Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0033504 floor plate development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048468 cell development
GO:0050767 regulation of neurogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RJ6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 222894
UniGene Hs.592168
RefSeq NP_690862
HUGO HGNC:16660
OMIM
CCDS CCDS5368
HPRD 16890
IMGT
EMBL AF369897 AF517122 BC069147 BC101135 BC101136 BC101137 BC101138 CH236948 CH471073
GenPept AAH69147 AAI01136 AAI01137 AAI01138 AAI01139 AAK72956 AAN04086 EAL24278 EAW93712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca