Version 5.4
Homo sapiens Protein: REXO4
Summary
InnateDB Protein IDBP-91281.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REXO4
Protein Name REX4, RNA exonuclease 4 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361010
InnateDB Gene IDBG-91279 (REXO4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:10908561, ECO:0000269PubMed:12429849}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004527 exonuclease activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
PFAM PF00929
PRINTS
PIRSF
SMART SM00479
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZR2
PhosphoSite PhosphoSite-Q9GZR2
TrEMBL B4E331
UniProt Splice Variant
Entrez Gene 57109
UniGene Hs.438409
RefSeq NP_065118
HUGO HGNC:12820
OMIM 602930
CCDS CCDS6969
HPRD 04239
IMGT
EMBL AF273304 AF295774 AK025493 AK295982 AK304547 AK314333 AK315904 AL136894 AL158826 BC009274 CH471090
GenPept AAF98162 AAG02123 AAH09274 BAB15152 BAG36979 BAG58757 BAG65343 BAH14275 CAB66828 CAI12845 CAI12847 CAI12848 CAI12849 EAW88082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca